Difference between Cholangiocarcinoma vs Gallbladder Cancer

Difference between Cholangiocarcinoma vs Gallbladder Cancer

Confusion may arise in patients suffering from any type of cancer of the digestive system due to the names cholangiocarcinoma and gallbladder cancer. Both conditions are rare but they may be severe and life-threatening if detected after some time. As the signs and symptoms of the condition tend to be the same, and patients often have a hard time comprehending which type of cancer they have and the trifling difference in treatment modalities possible for each type.  

In this blog, we will discuss the variations between gallbladder cancer and cholangiocarcinoma, the symptoms, causative factors, treatment modalities and the importance of consulting a specialist for accurate diagnosis and management.

Understanding Gallbladder Cancer

The gallbladder is an organ that is distributed under the liver and serves the function of storing bile which is useful in the digestion of fats. The gallbladder can be the site of cancer when gallbladder tissues undergo uncontrollable growth of malignant cells. 

Causes and Risk Factors of Gallbladder Cancer

There are several gallbladder cancer risk factors: 

  • Gallstones
  • Gallbladder chronic inflammation
  • A family history of gallbladder illness
  • Ageing
  • Obese and slothful

Symptoms of Gallbladder Cancer

In its early stages gallbladder cancer does not produce glaring symptoms but as it worsens, one can expect to notice: 

  • Abdominal pain 
  • Nauseous feelings
  • Digestion problems 
  • Skin and eye jaundice
  • Significant unintentional weight loss
  • Abdominal swelling

Understanding Cholangiocarcinoma

It is bile duct cancer which is the ducts that carry bile from the liver and gallbladder to the small intestine for digestion.

Risk Factors of Cholangiocarcinoma

The possible risk factors may include the following:

  • sclerosing cholangitis and other liver diseases
  • persistent liver infections
  • Inflammation of the bile ducts
  • bile ducts which have malformations
  • Liver infections due to parasites
  • Advanced biological age

Symptoms of Cholangiocarcinoma

Similar to gallbladder carcinoma, cholangiocarcinoma symptoms are non-specific and includes- 

  • Jaundice
  • Dark urine and light colored stools
  • Abdominal pain
  • Dry skin and sores
  • Weight loss and persistent exhaustion

Key Differences Between Gallbladder Cancer and Cholangiocarcinoma

While both cancers affect the biliary system, they differ in origin, presentation and treatment approach.

Feature

Gallbladder Cancer

Cholangiocarcinoma (Bile Duct Cancer)

Origin

Starts in the gallbladder

Starts in bile ducts

Common Risk Factor

Gallstones

Bile duct inflammation/liver disease

Early Symptoms

Often silent or mistaken for gallbladder disease

Jaundice, itching and dark urine

Diagnosis

Ultrasound, CT, MRI and biopsy

MRCP, ERCP, biopsy and  imaging

Treatment

Surgery, chemotherapy and targeted therapy

Surgery, stenting, chemotherapy and immunotherapy

Diagnosis and Treatment Options

Better outcomes come from timely diagnoses.

Methods of Diagnosis

Definitional Tests: Ultrasound, Computed Tomography and magnetic Resonance Imaging

Elective Tests: Liver Function Tests and Evaluation of Tumor Markers

Endoscopic Photography and Biopsy: to establish the type and stage of cancer

Options for Treatment

Surgery: The principal curative option available for timely detection

Tumor Reduction and Advanced Disease Management: May involve chemotherapy and radiation therapy.

Survival rate improving techniques: Targeted and immunotherapy

Advanced stage: Requiring palliative care for symptomatology

Why Choose Dr. Pooja Babbar for Cancer Treatment in Gurgaon

The journey ahead is very important when someone has been diagnosed with cancer. Dr. Pooja Babbar, Best Medical Oncologist in Gurgaon is known for her expertise in treating difficult cases of gastrointestinal cancers such as cholangiocarcinoma, gallbladder and liver cancer.

Her patients benefit from:

Achieved Outcomes: Successfully managed unique and difficult cancers.

Care Pathways: Developed to be as unique as the individual’s diagnosis and medical history.

Innovative Methods: Harnessing the power of targeted therapy and immunotherapy.

Empathetic Advocacy: The primary contact of patient and the person who will provide them with guidance, referrals and assistance during the entire journey.

Conclusion

Gallbladder carcinoma and cholangiocarcinoma may look alike but they are profoundly different in their points of origin, manifestations and treatments. Appreciating such aspects enables patients to screen themselves and seek timely suitable treatment.

If you or someone close to you has continuous abdominal pain, persistent itching, jaundice or any such worrying complaints, you should act without delay. Schedule an appointment with Dr. Pooja Babbar is one of the best medical oncologists in Gurgaon, who will accurately diagnose you and provide individualized care and treatment while delivering high-quality services.

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